This course presents both basic and advanced concepts of immunology. The basic concepts presented include but are not limited to: function of the innate defense mechanisms, antigens, development of the immune system, lymphocytes, immunoglobulins, lymphokines and inflammation. Advanced concepts that will be presented are: B and T-lymphocyte ontogeny, generation of antibody diversity and genetics of the major histocompatibility complex and cytokine networks. Following the successful completion of the course, the student should have a firm understanding of the organization, function and operation of the immune system in the defense against viruses, bacteria, fungi, parasites, tumors and transplanted organs.